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St. Jude discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme.

1 Jun 2023

Artificial viral vectors constructed from bacteriophage T4 show promise for advanced gene delivery

Research presents an assembly-line approach using bacteriophage T4 components to construct artificial viral vectors (AVVs). These AVVs have the potential to revolutionize gene therapies and personalized medicine by enabling the efficient delivery of biomolecules for molecular repairs and genome remodeling.

1 Jun 2023

New genetic risk factors for Alzheimer’s disease unique to Ashkenazi Jews identified

Alzheimer disease (AD), the most common neurodegenerative disorder in the world, affects individuals of all races and ethnicities; however, most genetic research for AD has been performed on individuals of European ancestry (EA) with a limited number of large-scale genetic studies in other populations.

1 Jun 2023

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles.

1 Jun 2023

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Researchers from Children's Hospital of Philadelphia (CHOP) recently discovered that extremely thorough "deep sequencing" of the genome in tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies captured several genetic variants related to disease that were not captured with conventional genetic sequencing methods.

1 Jun 2023

Accounting for genetic factors can improve accuracy of prostate cancer screening

The accuracy of prostate-specific antigen (PSA) screening for prostate cancer can be improved by accounting for genetic factors that cause changes in PSA levels that are not associated with cancer, according to a multi-center study led by UC San Francisco and Stanford University.

1 Jun 2023

Real-world management and outcomes of U.S. patients treated with BpaL for rifampin-resistant tuberculosis

Researchers reported on the treatment of rifampin-resistant tuberculosis in the United States using the FDA approved bedaquiline, pretomanid, and linezolid (BPaL) therapy.

1 Jun 2023

CardioGen upgrade facilitates more accurate diagnosis of monogenic cardiovascular diseases

Over 2,800 cases, representing a 31% increase, added to BGI Genomics-led CardioGen's hereditary cardiovascular disease gene data.

From BGI Genomics 1 Jun 2023

Multi-ethnic genome study unlocks new genetic links to health conditions

Research explores the genetic architecture of circulating metabolites, uncovering novel variant-metabolite associations and validating previous findings. It provides insights into the genetic contribution to metabolite levels and potential implications for human disease.

31 May 2023

NIH scientists identify genomic variants that cause rare inflammatory skin disorder

Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.

31 May 2023

New variants of human metapneumovirus surge in Spain post-COVID, highlighting evolution and impact

Investigating Human metapneumovirus (HMPV) prevalence, genetic diversity, and evolution in respiratory tract infections (RTIs) for better understanding and management.

31 May 2023

Researchers create an open-source, reproducible analysis platform for pediatric brain tumors

Researchers from Children's Hospital of Philadelphia, the Alex's Lemonade Stand Foundation Childhood Cancer Data Lab, the Children's Brain Tumor Network, the Pacific Pediatric Neuro-Oncology Consortium, and more than 20 additional institutions have partnered to create a first-of-its-kind open-source, reproducible analysis platform for pediatric brain tumors.

31 May 2023

Chemical found in widely used sweetener breaks up DNA

A new study finds a chemical formed when we digest a widely used sweetener is "genotoxic," meaning it breaks up DNA.

31 May 2023

Environmental enrichment may reduce early accumulation of amyloid plaques in Alzheimer's mouse model

About two-thirds of the risk for Alzheimer's disease (AD) is thought to arise from genetic influences, but about a third could be influenced by environment and lifestyle, opening the door for behavioral interventions that could delay or prevent pathophysiological changes that occur with AD.

31 May 2023

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

Scientists have identified a lipid-degrading enzyme as a prognostic biomarker for luminal breast cancer.

31 May 2023

North American arrival of A(H5N1) influenza raises concerns of potential pandemic outbreak

Rapid global expansion of highly pathogenic avian influenza A(H5N1) viruses in 2021, including reassortment with North American strains, highlights the need for proactive measures to combat their spread and mitigate the risk of a potential pandemic originating from these reassortants.

31 May 2023

Largest clinical case series of laughing gas users finds a predominance of young Asian men

The largest clinical case series to date of recreational users of nitrous oxide, popularly known as laughing gas, has found a predominance of young men of Asian ethnicity among those with neurological side effects who were seen at hospitals in 3 major cities in England.

30 May 2023

Aggressive lung pathogen may not be prone to person-to-person transmission

A little-known bacterium -; a distant cousin of the microbes that cause tuberculosis and leprosy -; is emerging as a public health threat capable of causing severe lung infections among vulnerable populations, those with compromised immunity or reduced lung function.

30 May 2023

Computational approach could help pinpoint causal variants in the noncoding genome

Less than two percent of the human genome codes for proteins, with the rest being noncoding and likely helping with gene regulation.

30 May 2023

Experimental decoy provides long-term protection from SARS-Cov-2 infection

An experimental "decoy" provided long-term protection from infection by the pandemic virus in mice, a new study finds.

30 May 2023

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Genetic News and Research

St. Jude discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Artificial viral vectors constructed from bacteriophage T4 show promise for advanced gene delivery

New genetic risk factors for Alzheimer’s disease unique to Ashkenazi Jews identified

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Accounting for genetic factors can improve accuracy of prostate cancer screening

Real-world management and outcomes of U.S. patients treated with BpaL for rifampin-resistant tuberculosis

CardioGen upgrade facilitates more accurate diagnosis of monogenic cardiovascular diseases

Multi-ethnic genome study unlocks new genetic links to health conditions

NIH scientists identify genomic variants that cause rare inflammatory skin disorder

New variants of human metapneumovirus surge in Spain post-COVID, highlighting evolution and impact

Researchers create an open-source, reproducible analysis platform for pediatric brain tumors

Chemical found in widely used sweetener breaks up DNA

Environmental enrichment may reduce early accumulation of amyloid plaques in Alzheimer's mouse model

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

North American arrival of A(H5N1) influenza raises concerns of potential pandemic outbreak

Largest clinical case series of laughing gas users finds a predominance of young Asian men

Aggressive lung pathogen may not be prone to person-to-person transmission

Computational approach could help pinpoint causal variants in the noncoding genome

Experimental decoy provides long-term protection from SARS-Cov-2 infection

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