Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

RNA regulatory mechanism could be targeted to slow AD progression mediated by stress granules

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Stress granules sequester Alzheimer's disease-associated gene transcripts and regulate disease-related neuronal proteostasis."

1 Jun 2023

New genetic risk factors for Alzheimer’s disease unique to Ashkenazi Jews identified

Alzheimer disease (AD), the most common neurodegenerative disorder in the world, affects individuals of all races and ethnicities; however, most genetic research for AD has been performed on individuals of European ancestry (EA) with a limited number of large-scale genetic studies in other populations.

1 Jun 2023

Pilot study reveals effective approach to boost adherence to Mediterranean ketogenic diet for memory concerns in older adults

Researchers explored strategies for enhancing compliance with a Mediterranean ketogenic nutrition program among older individuals.

1 Jun 2023

Study explores the link between sleep apnea and brain volume

Studies have shown that sleep apnea is related to an increased risk of dementia. A new study looks at the relationship between sleep apnea and brain volume.

31 May 2023

Environmental enrichment may reduce early accumulation of amyloid plaques in Alzheimer's mouse model

About two-thirds of the risk for Alzheimer's disease (AD) is thought to arise from genetic influences, but about a third could be influenced by environment and lifestyle, opening the door for behavioral interventions that could delay or prevent pathophysiological changes that occur with AD.

31 May 2023

Biomarker study reveals the effects of astrocyte reactivity in preclinical Alzheimer's disease

Evidence supports a close link between Aβ, astrocyte reactivity, and tau pathology in preclinical AD.

31 May 2023

Research finds more depressed patients with activated immune systems than previously estimated

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London has used an assessment of gene expression involved in the immune response to show that there could be more patients with MDD with activated immune systems than research has previously estimated.

30 May 2023

New research shows astrocytes are key to swaying the pendulum in Alzheimer's disease progression

Why do some people develop Alzheimer's disease while others don't? And, even more puzzlingly, why do many individuals whose brains are chock-full of toxic amyloid aggregates-;a telltale sign of Alzheimer's brain pathology-;never go on to develop Alzheimer's-associated dementias?

29 May 2023

Simple, low-cost clip uses a smartphone's camera and flash to monitor blood pressure

Engineers at the University of California San Diego have developed a simple, low-cost clip that uses a smartphone's camera and flash to monitor blood pressure at the user's fingertip.

29 May 2023

Modest reduction in beta-amyloidogenic processing of APP may be a viable strategy to prevent Alzheimer's disease

A new study conducted by researchers at the University of Eastern Finland discovered that the APP A673T genetic variant, which protects against Alzheimer’s disease, alters levels of several proteins and peptides linked to amyloid-beta metabolism in human biofluids and cell culture models, including amyloid beta itself.

26 May 2023

Tracking changes in blood vessels may hold clues to early detection of neurodegenerative diseases

While age-related brain disorders like Alzheimer's disease often develop slowly across an individual's lifetime, they usually aren't detected until symptoms have already started.

26 May 2023

$4.5 million grant to fund research exploring link between exercise and slowing Alzheimer's progression

A $4.5 million groundbreaking grant will fund research to explore a promising link between aerobic exercise and slowing the progression of Alzheimer's disease in a study led by an Arizona State University researcher.

26 May 2023

Case study: Experimental lecanemab treatment causes adverse outcomes in 65-year-old woman with Alzheimer's disease

In a noteworthy case study published in the Journal of Alzheimer's Disease investigators report autopsy findings in a 65-year-old woman with Alzheimer's disease (AD) who received three open label infusions of the experimental anti-amyloid beta (Aβ) antibody drug lecanemab.

25 May 2023

Alzheimer’s development: Study reveals why apoE4 gene fails to protect the brain from inflammation

A possible explanation has been found in a study for why apoE4, the most significant genetic risk factor associated with Alzheimer's disease, fails to protect the brain from inflammation.

25 May 2023

Superior cognition in individuals who are 90+ associated with resilience to neurodegenerative pathologies

A University of California, Irvine-led team of researchers have discovered that the oldest-old, those who live to be 90+ and have superior cognitive skills, have similar levels of brain pathology as Alzheimer's patients, however, they also have less brain pathology of other neurodegenerative diseases that cause memory and thinking problems.

25 May 2023

People with Alzheimer's disease more likely to develop epilepsy and vice versa

People with a genetic predisposition for Alzheimer's disease may have an increased risk of epilepsy and people with a certain type of epilepsy may have an increased risk of developing Alzheimer's disease, according to a study published in the May 24, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

25 May 2023

Chocoholics rejoice: Regular chocolate consumption linked to slightly lower risk of mortality in women

Researchers examine the relationship between chocolate consumption and mortality in women.

23 May 2023

Metabolic sensors may play a role in the development of Alzheimer's disease, study suggests

It's well-known that people with Type 2 diabetes are at an increased risk of developing Alzheimer's disease, but the reason why isn't fully understood and is an area of current research.

22 May 2023

Gout unveiled as surprising culprit in neurodegenerative diseases

Research highlights the association between gout and neurodegenerative diseases, revealing that gout patients exhibit smaller brain volumes, increased brain iron markers, and a higher incidence of conditions such as dementia, Parkinson's disease, and essential tremor, particularly within the first three years after diagnosis.

22 May 2023

Newly discovered molecule effectively destroys senescent cells

Over time, the body's cells stop working properly and begin to accumulate, which eventually leads to tissues aging.

22 May 2023

Alzheimer's Disease News and Research

Further Reading

RNA regulatory mechanism could be targeted to slow AD progression mediated by stress granules

New genetic risk factors for Alzheimer’s disease unique to Ashkenazi Jews identified

Pilot study reveals effective approach to boost adherence to Mediterranean ketogenic diet for memory concerns in older adults

Study explores the link between sleep apnea and brain volume

Environmental enrichment may reduce early accumulation of amyloid plaques in Alzheimer's mouse model

Biomarker study reveals the effects of astrocyte reactivity in preclinical Alzheimer's disease

Research finds more depressed patients with activated immune systems than previously estimated

New research shows astrocytes are key to swaying the pendulum in Alzheimer's disease progression

Simple, low-cost clip uses a smartphone's camera and flash to monitor blood pressure

Modest reduction in beta-amyloidogenic processing of APP may be a viable strategy to prevent Alzheimer's disease

Tracking changes in blood vessels may hold clues to early detection of neurodegenerative diseases

$4.5 million grant to fund research exploring link between exercise and slowing Alzheimer's progression

Case study: Experimental lecanemab treatment causes adverse outcomes in 65-year-old woman with Alzheimer's disease

Alzheimer’s development: Study reveals why apoE4 gene fails to protect the brain from inflammation

Superior cognition in individuals who are 90+ associated with resilience to neurodegenerative pathologies

People with Alzheimer's disease more likely to develop epilepsy and vice versa

Chocoholics rejoice: Regular chocolate consumption linked to slightly lower risk of mortality in women

Metabolic sensors may play a role in the development of Alzheimer's disease, study suggests

Gout unveiled as surprising culprit in neurodegenerative diseases

Newly discovered molecule effectively destroys senescent cells

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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