Alzheimer's Disease - May 30, 2023 - Chocoholics rejoice: Regular chocolate consumption linked to slightly lower risk of mortality in women

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	Alzheimer's Disease
	The latest Alzheimer's disease news from News Medical

	Chocoholics rejoice: Regular chocolate consumption linked to slightly lower risk of mortality in women Researchers examine the relationship between chocolate consumption and mortality in women.

	Superior cognition in individuals who are 90+ associated with resilience to neurodegenerative pathologies A University of California, Irvine-led team of researchers have discovered that the oldest-old, those who live to be 90+ and have superior cognitive skills, have similar levels of brain pathology as Alzheimer's patients, however, they also have less brain pathology of other neurodegenerative diseases that cause memory and thinking problems.

			Study shows an association between type 2 diabetes and developing dementia in later life New research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) shows an association between type 2 diabetes (T2D) and developing dementia in later life – with the risk of dementia increasing the earlier a person develops T2D.

			Diet low in flavanols linked to age-related memory loss A large-scale study led by researchers at Columbia and Brigham and Women's Hospital/Harvard is the first to establish that a diet low in flavanols-;nutrients found in certain fruits and vegetables-;drives age-related memory loss.

			Insights into the direction and extent of gut microbiome dysbiosis in Alzheimer’s disease and mild cognitive impairment Researchers performed a meta-analysis to determine the association between intestinal microbiota and Alzheimer’s disease (AD).

	Daily multivitamin supplementation holds promise to protect cognitive health in older adults Few effective strategies have been shown in randomized clinical trials to improve memory or slow cognitive decline among older adults.

	Case study: Experimental lecanemab treatment causes adverse outcomes in 65-year-old woman with Alzheimer's disease In a noteworthy case study published in the Journal of Alzheimer's Disease investigators report autopsy findings in a 65-year-old woman with Alzheimer's disease (AD) who received three open label infusions of the experimental anti-amyloid beta (Aβ) antibody drug lecanemab.

	Modest reduction in beta-amyloidogenic processing of APP may be a viable strategy to prevent Alzheimer's disease A new study conducted by researchers at the University of Eastern Finland discovered that the APP A673T genetic variant, which protects against Alzheimer’s disease, alters levels of several proteins and peptides linked to amyloid-beta metabolism in human biofluids and cell culture models, including amyloid beta itself.

	New research shows astrocytes are key to swaying the pendulum in Alzheimer's disease progression Why do some people develop Alzheimer's disease while others don't? And, even more puzzlingly, why do many individuals whose brains are chock-full of toxic amyloid aggregates-;a telltale sign of Alzheimer's brain pathology-;never go on to develop Alzheimer's-associated dementias?

	Tracking changes in blood vessels may hold clues to early detection of neurodegenerative diseases While age-related brain disorders like Alzheimer's disease often develop slowly across an individual's lifetime, they usually aren't detected until symptoms have already started.

	Two key physiological systems found to be involved in high-salt-induced hypertension and dementia Dementia is defined as the loss of cognitive functioning-;including thinking, remembering, and reasoning-;and is very prevalent in Japan.

	T-cell-inducing mRNA COVID-19 vaccine improves effectiveness Researchers develop a lipid nanoparticle-formulated mRNA-based antigen encoding three SARS-CoV-2 peptides derived from non-structural proteins.

	Bridging the gap between academia and industry: The power of collaboration in life sciences In this behind-the-scenes interview, we speak to Dr. Sinead Knight, chair of SLAS Europe 2023, about this years programme, highlighting the key topics and speakers.

	$11.6 million NIDA grant supports the study of cannabis effects on HIV-infected brains Weill Cornell Medicine has been awarded a five-year, $11.6 million grant from the National Institute on Drug Abuse of the National Institutes of Health to study the effects cannabis, including marijuana and compounds derived from it, may have on the brains of those living with HIV.

	Alzheimer’s development: Study reveals why apoE4 gene fails to protect the brain from inflammation A possible explanation has been found in a study for why apoE4, the most significant genetic risk factor associated with Alzheimer's disease, fails to protect the brain from inflammation.

	People with Alzheimer's disease more likely to develop epilepsy and vice versa People with a genetic predisposition for Alzheimer's disease may have an increased risk of epilepsy and people with a certain type of epilepsy may have an increased risk of developing Alzheimer's disease, according to a study published in the May 24, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

	Examining first treatment for strokes linked to dementia People who experience a type of stroke linked with nearly half of all dementias could be treated for the first time by repurposing two cheap and common drugs, a trial shows.

	$4.5 million grant to fund research exploring link between exercise and slowing Alzheimer's progression A $4.5 million groundbreaking grant will fund research to explore a promising link between aerobic exercise and slowing the progression of Alzheimer's disease in a study led by an Arizona State University researcher.

	Genetic predisposition to lipids, Alzheimer’s and heart disease in MLXIPL gene shaped by exogenous exposures A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, "Exogenous exposures shape genetic predisposition to lipids, Alzheimer's, and coronary heart disease in the MLXIPL gene locus."