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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Artificial viral vectors constructed from bacteriophage T4 show promise for advanced gene delivery

Research presents an assembly-line approach using bacteriophage T4 components to construct artificial viral vectors (AVVs). These AVVs have the potential to revolutionize gene therapies and personalized medicine by enabling the efficient delivery of biomolecules for molecular repairs and genome remodeling.

1 Jun 2023

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Researchers from Children's Hospital of Philadelphia (CHOP) recently discovered that extremely thorough "deep sequencing" of the genome in tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies captured several genetic variants related to disease that were not captured with conventional genetic sequencing methods.

1 Jun 2023

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research.

1 Jun 2023

Real-world management and outcomes of U.S. patients treated with BpaL for rifampin-resistant tuberculosis

Researchers reported on the treatment of rifampin-resistant tuberculosis in the United States using the FDA approved bedaquiline, pretomanid, and linezolid (BPaL) therapy.

1 Jun 2023

Wastewater data unveils underreported Mpox cases in Texas

A recent study characterizes the analytical sensitivity of three assays used to detect MPXV in wastewater samples.

31 May 2023

Chemical found in widely used sweetener breaks up DNA

A new study finds a chemical formed when we digest a widely used sweetener is "genotoxic," meaning it breaks up DNA.

31 May 2023

Green Mediterranean diet reshapes DNA methylation, boosts metabolism

Study explores the effects of a green-MED diet enriched in polyphenols and reduced in red/processed meat on the methylome and transcriptome levels. It aims to uncover the molecular mechanisms underlying the observed metabolic improvements.

30 May 2023

Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Melatonin, a hormone derived from the pineal gland, has diverse effects on cellular processes. This review explores its potential role as an epigenetic regulator, particularly in modulating DNA methylation, and suggests its use in combination therapy as a novel anticancer strategy.

30 May 2023

Verifying the healthcare, nutritional and environmental applications of new Antarctic bacteria

A scientific collaboration between the University of São Paulo (USP) in Ribeirão Preto, Brazil, and Clemente Estable Institute of Biological Research (IIBCE) in Montevideo, Uruguay, is experimenting with two new bacteria discovered in the Antarctic ten years ago, in order to verify the possibility of applications in healthcare, food processing and environmental rehabilitation.

30 May 2023

DNA test results may enhance prevention and treatment of alcohol use disorder

Today's substance use prevention efforts ignore individual genetic risk, but Rutgers research suggests DNA test results may eventually enhance prevention and treatment and improve outcomes.

30 May 2023

Alternative gene splicing can impact the risk for alcohol use disorder

Researchers at Indiana University School of Medicine have discovered alternative gene splicing, which occurs during gene expression, can impact a person's risk of alcohol use disorder (AUD).

30 May 2023

Researchers find oldest evidence of the plague in Britain to date

Researchers at the Francis Crick Institute have identified three 4,000-year-old British cases of Yersinia pestis, the bacteria causing the plague – the oldest evidence of the plague in Britain to date, reported in a paper published today in Nature Communications.

30 May 2023

Mammograms at 40? Breast cancer screening guidelines spark fresh debate

While physicians mostly applauded a government-appointed panel's recommendation that women get routine mammography screening for breast cancer starting at age 40, down from 50, not everyone approves.

30 May 2023

Obesity strikes below the belt: Study reveals link between obesity and male infertility

The influence of obesity on male fertility is still under debate. In the present investigation, researchers scrutinized semen samples from both obese individuals and those of normal weight. The aim was to explore the relationship between obesity, the length of sperm telomeres, levels of mRNA associated with autophagy, and diverse semen characteristics.

29 May 2023

Artificial intelligence in sperm selection for assisted reproduction

Researchers summarize available evidence on the application of artificial intelligence and machine learning in sperm selection.

29 May 2023

Fission yeast study sheds new light on gross chromosomal rearrangement

When creating a computer program, errors in the code can introduce bugs to the software. Similarly, errors in our body's genetic code, DNA, which is stored in structures known as chromosomes, can bring about mutations in the body.

26 May 2023

Researchers explore the possibility of treating lung cancer by targeting telomeres

Healthy cells can only divide a limited number of times during an organism's lifetime. In contrast, tumor cells are immortal: they proliferate indefinitely and uncontrollably, and this is the defining characteristic of cancer.

26 May 2023

Makeup of microbiome in a person's tumor varies depending on early or late-onset colorectal cancer

Researchers at Georgetown University's Lombardi Comprehensive Cancer Center studied the microbiome of people with colorectal cancer and found the make-up of the bacteria, fungi and viruses in a person's tumor varied significantly depending on whether they were diagnosed with early-onset disease (age 45 or younger) or late-onset disease (age 65 or older).

26 May 2023

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to this year's recipient of the Pittsburgh Analytical Chemistry Award, Neil Kelleher, about his work in top-down proteinomics.

From Pittcon 26 May 2023

Groundbreaking study targets 'jumping genes' in the entire genomes of the human large intestine

The Korea Advanced Institute of Science and Technology (KAIST) and their collaborators have conducted a groundbreaking study targeting 'jumping genes' in the entire genomes of the human large intestine.

25 May 2023

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DNA News and Research

Further Reading

Artificial viral vectors constructed from bacteriophage T4 show promise for advanced gene delivery

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

Real-world management and outcomes of U.S. patients treated with BpaL for rifampin-resistant tuberculosis

Wastewater data unveils underreported Mpox cases in Texas

Chemical found in widely used sweetener breaks up DNA

Green Mediterranean diet reshapes DNA methylation, boosts metabolism

Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Verifying the healthcare, nutritional and environmental applications of new Antarctic bacteria

DNA test results may enhance prevention and treatment of alcohol use disorder

Alternative gene splicing can impact the risk for alcohol use disorder

Researchers find oldest evidence of the plague in Britain to date

Mammograms at 40? Breast cancer screening guidelines spark fresh debate

Obesity strikes below the belt: Study reveals link between obesity and male infertility

Artificial intelligence in sperm selection for assisted reproduction

Fission yeast study sheds new light on gross chromosomal rearrangement

Researchers explore the possibility of treating lung cancer by targeting telomeres

Makeup of microbiome in a person's tumor varies depending on early or late-onset colorectal cancer

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

Groundbreaking study targets 'jumping genes' in the entire genomes of the human large intestine

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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