Scientists uncover how some skin cancers resist treatment at the end of life

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	Skin Cancer
	The latest skin cancer news from News Medical

Scientists uncover how some skin cancers resist treatment at the end of life

An in-depth analysis of 14 patients who died from incurable melanoma has revealed that changes to the order, structure and number of copies of tumor DNA could cause some skin cancers to resist treatment. These changes also explain how melanoma can spread to other parts of the body.

Explore the Research

			CD9-positive exosomes inhibit the growth of malignant melanoma, study suggests Malignant melanoma is a relatively aggressive type of skin cancer. When detected early, it is usually treatable by surgical resection only, but metastases develop often spreading to distant areas.

			New therapeutic approach to eliminate aging cells by boosting anti-viral immune response Aging, or senescent cells, which stop dividing but don't die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders.

	Immunotherapy response in patients with advanced melanoma depends on prior treatments Research led by scientists at UCLA Jonsson Comprehensive Cancer Center found that responses to a type of immunotherapy called PD-1 checkpoint blockade in patients with advanced melanoma depended on whether or not they had previously received another immunotherapy – CTLA-4 blockade – as well as other factors.

	Clearance of senescent cells by boosting anti-viral immune response Aging, or senescent cells, which stop dividing but don't die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders.

	Additional therapeutic maneuver may be needed to stop some metastasized tumors Cancer that has spread to areas like the lungs can apply the brakes to a natural pathway that should recruit killer T cells directly to where it has metastasized, scientists report.

	Mount Sinai to expand research training program in skin biology with support from $1.3 million T32 grant The Kimberly and Eric J. Waldman Department of Dermatology at the Icahn School of Medicine at Mount Sinai will expand its research training program in skin biology with support from a five-year, $1.3 million T32 grant from the National Institutes of Health and the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

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