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Passing on Polycystic Ovary Syndrome: Health risks for Male offspring of Women with PCOS

In this interview, we spoke to two researchers from the Karolinska Institutet about their latest work that investigated how PCOS can affect the health of future generations of men.

29 May 2023

First-in-human nanoparticle HIV vaccine induces broad and publicly targeted helper T cell responses

Researchers from Fred Hutchinson Cancer Center in Seattle, Scripps Research in La Jolla, California, IAVI and other collaborating institutions have characterized robust T-cell responses in volunteers participating in the IAVI G001 Phase 1 clinical trial to test the safety and immune response of a self-assembling nanoparticle HIV vaccine.

25 May 2023

A novel approach to quantify personal information contained within gut metagenome data

Researchers used shotgun sequencing to extract human reads from DNA in fecal samples

17 May 2023

New liquid biopsy tool shows 30% increased sensitivity in detecting ctDNA

Pancreatic cancer is the seventh leading cause of cancer death worldwide and despite the increasing incidence of this disease, effective treatments are lacking and prognosis for patients with this tumor type remains poor, with approximately 70% of patients dying within one year of diagnosis.

16 May 2023

New CRISPR genome-editing technology helps scientists to explore many cancer-linked mutations

Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development.

11 May 2023

Wistar scientists uncover a key mechanism as to how p53 suppresses tumors

The p53 gene is one of the most important in the human genome: the only role of the p53 protein that this gene encodes is to sense when a tumor is forming and to kill it.

5 May 2023

Research reveals molecular features of rare mtDNA mutations

A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for assessing mtDNA editing strategies and genetic diagnosis of embryos prior to their implantation.

13 Apr 2023

New method estimates mutation risks due to residual radiation from the Fukushima nuclear disaster

Ionizing radiation from nuclear disasters are known to be harmful to the natural environment. The Fukushima Dai-ichi Nuclear Power Plant meltdown that occurred in 2011 is a prominent example of such a disaster in recent memory.

7 Apr 2023

Discovery may change the way people think about immune strategies

The human body is capable of creating a vast, diverse repertoire of antibodies-;the Y-shaped sniffer dogs of the immune system that can find and flag foreign invaders.

7 Apr 2023

Cold temperature plays a central role in longevity

Cold activates a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging.

3 Apr 2023

Study identifies ultra-broad SARS-CoV-2 neutralizing antibodies that target various spike epitopes

Researchers screened the circulating B lymphocyte repertoires of coronavirus disease 2019 convalescents and vaccines using multiplexed antigen panels.

3 Apr 2023

Why are colon cancer rates in young people rising?

In a recent perspective article published in the journal Science, researchers at the Young-Onset Colorectal Cancer Center of Dana-Farber Cancer Institute emphasized that a better understanding of the etiology of early-onset colorectal cancer (EOCRC) is crucial to managing its increasing incidence worldwide

21 Mar 2023

Study highlights poor clinical utility of germline testing in cancer patients of African ancestry

New research in the March 2023 issue of JNCCN-; Journal of the National Comprehensive Cancer Network highlights how the lack of genomic research for people with African ancestry, particularly those from the Sub-Saharan region, is hampering efforts to reduce disparities for people with cancer.

10 Mar 2023

Study highlights the interconnectedness of autoimmunity and cancer

In a recent study published in the journal Immunity, researchers reviewed the T cell response in cancer and autoimmunity to propose strategies for more effective immunotherapies.

15 Feb 2023

Public attitudes of Americans towards polygenic embryo selection

In a Policy Forum, Michelle Meyer and colleagues present insights from a survey – a first of its kind – exploring the public attitudes of thousands of Americans towards polygenic embryo selection.

9 Feb 2023

Study evaluates benefits of implementing a pharmacogenetic panel before drug initiation

In a recent study published in The Lancet, researchers performed an implementation study of a 12-gene pharmacogenetic panel across seven European countries to investigate whether a gene-drug interaction guidedinteraction-guided prescribing strategy could prevent its adverse reactions.

8 Feb 2023

Germline News and Research

Passing on Polycystic Ovary Syndrome: Health risks for Male offspring of Women with PCOS

First-in-human nanoparticle HIV vaccine induces broad and publicly targeted helper T cell responses

A novel approach to quantify personal information contained within gut metagenome data

New liquid biopsy tool shows 30% increased sensitivity in detecting ctDNA

New CRISPR genome-editing technology helps scientists to explore many cancer-linked mutations

Wistar scientists uncover a key mechanism as to how p53 suppresses tumors

Research reveals molecular features of rare mtDNA mutations

New method estimates mutation risks due to residual radiation from the Fukushima nuclear disaster

Discovery may change the way people think about immune strategies

Cold temperature plays a central role in longevity

Study identifies ultra-broad SARS-CoV-2 neutralizing antibodies that target various spike epitopes

Why are colon cancer rates in young people rising?

Study highlights poor clinical utility of germline testing in cancer patients of African ancestry

Study highlights the interconnectedness of autoimmunity and cancer

Public attitudes of Americans towards polygenic embryo selection

Study evaluates benefits of implementing a pharmacogenetic panel before drug initiation

New research may explain why some patients suffer from long-COVID

Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

Adding veliparib to chemotherapy can extend progression-free survival in patients with “BRCA-like” breast cancer

Novel method makes genetic analyses possible for all regions of the intestine

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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