Phenotype News and Research

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MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

MFAP5, a microfibril-associated protein, plays a significant role in wound healing by regulating fibroblast function, collagen deposition, and angiogenesis, suggesting its potential as a modulator of scar formation.

1 Jun 2023

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Researchers from Children's Hospital of Philadelphia (CHOP) recently discovered that extremely thorough "deep sequencing" of the genome in tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies captured several genetic variants related to disease that were not captured with conventional genetic sequencing methods.

1 Jun 2023

CardioGen upgrade facilitates more accurate diagnosis of monogenic cardiovascular diseases

Over 2,800 cases, representing a 31% increase, added to BGI Genomics-led CardioGen's hereditary cardiovascular disease gene data.

From BGI Genomics 1 Jun 2023

Multi-ethnic genome study unlocks new genetic links to health conditions

Research explores the genetic architecture of circulating metabolites, uncovering novel variant-metabolite associations and validating previous findings. It provides insights into the genetic contribution to metabolite levels and potential implications for human disease.

31 May 2023

A deeper look into axial spondyloarthritis: Prevalence, diagnosis, and treatment

There is a large diagnostic delay for people with axial spondyloarthritis (axSpA). In 2008, the SPACE cohort started to assess the prevalence of axSpA – and the reliability of an early diagnosis in people with chronic back pain (CBP).

31 May 2023

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

Scientists have identified a lipid-degrading enzyme as a prognostic biomarker for luminal breast cancer.

31 May 2023

The immunopathology of post-acute sequelae of SARS-CoV-2 infection: highlighting the knowledge gaps

The immunopathology of post-acute sequelae of SARS-CoV-2 infection (PASC).

31 May 2023

Using ex vivo gene therapy to fight obesity and diabetes in mice

A scientific team from the University of Barcelona and the CIBERobn has designed a strategy to fight obesity and diabetes in mice through ex vivo gene therapy which consists of implanting cells that have been manipulated and transformed in order to treat a disease.

30 May 2023

Mental health profoundly impacts inflammatory responses in the body

Study uncovered mechanisms by which psychological stress affects bowel inflammation.

30 May 2023

Passing on Polycystic Ovary Syndrome: Health risks for Male offspring of Women with PCOS

In this interview, we spoke to two researchers from the Karolinska Institutet about their latest work that investigated how PCOS can affect the health of future generations of men.

29 May 2023

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to this year's recipient of the Pittsburgh Analytical Chemistry Award, Neil Kelleher, about his work in top-down proteinomics.

From Pittcon 26 May 2023

First-in-human nanoparticle HIV vaccine induces broad and publicly targeted helper T cell responses

Researchers from Fred Hutchinson Cancer Center in Seattle, Scripps Research in La Jolla, California, IAVI and other collaborating institutions have characterized robust T-cell responses in volunteers participating in the IAVI G001 Phase 1 clinical trial to test the safety and immune response of a self-assembling nanoparticle HIV vaccine.

25 May 2023

Exercise capacity found to be lower than expected among people with long COVID

While some patients recover from the effects of SARS-CoV-2 infection, others have experienced the aftereffects of COVID-19 long after the initial infection. One of these long COVID symptoms is reduced exercise capacity.

25 May 2023

Higher intake of flavonol-rich foods linked to lower odds of developing frailty

Eating plant-based foods that contain dietary compounds called flavonols can lower your chances of developing frailty.

23 May 2023

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Writing in the May 22, 2023 issue of Cell Systems, a diverse team of scientists, led by researchers at University of California San Diego School of Medicine, have produced a novel map that depicts the human body's enormously complicated and highly evolved system for addressing and repairing DNA damage -; a cause and consequence of many diseases.

22 May 2023

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Research describes the development of a synthetic delivery vector called STxB for mucosal vaccination. It induces mucosal immunity, including resident memory CD8+ T cells and IgA antibodies, against antigens derived from mucosal viruses when administered intranasally in mice.

21 May 2023

Unraveling how the interplay between Sargassum, plastic marine debris and Vibrio bacteria creates the perfect "pathogen" storm

A new study uncovers how the interplay between Sargassum spp., plastic marine debris and Vibrio bacteria creates the perfect "pathogen" storm that has implications for both marine life and public health. Vibrio bacteria are found in waters around the world and are the dominant cause of death in humans from the marine environment.

18 May 2023

Does obstructive sleep apnea increase the risk of post-acute sequelae of SARS-CoV-2?

Research paper examines the potential link between obstructive sleep apnea (OSA) and Post-Acute Sequelae of SARS-CoV-2 (PASC), the long-term effects of COVID-19. It investigates whether OSA increases the risk of more severe PASC outcomes.

15 May 2023

Metabolically healthy and unhealthy 'forms' of obesity linked with increased risk of obesity-related cancers

New research to be presented at this coming week's European Congress on Obesity in Dublin, Ireland (17-20 May) and published in the Journal of the National Cancer Institute shows that both the metabolically healthy and unhealthy 'forms' of obesity are associated with an increased risk of various obesity-related cancers, with the relationship stronger in metabolically unhealthy obesity.

15 May 2023

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

Researchers conducted a phase I clinical trial of a personalized mRNA neoantigen vaccine.

12 May 2023

Phenotype News and Research

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

CardioGen upgrade facilitates more accurate diagnosis of monogenic cardiovascular diseases

Multi-ethnic genome study unlocks new genetic links to health conditions

A deeper look into axial spondyloarthritis: Prevalence, diagnosis, and treatment

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

The immunopathology of post-acute sequelae of SARS-CoV-2 infection: highlighting the knowledge gaps

Using ex vivo gene therapy to fight obesity and diabetes in mice

Mental health profoundly impacts inflammatory responses in the body

Passing on Polycystic Ovary Syndrome: Health risks for Male offspring of Women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

First-in-human nanoparticle HIV vaccine induces broad and publicly targeted helper T cell responses

Exercise capacity found to be lower than expected among people with long COVID

Higher intake of flavonol-rich foods linked to lower odds of developing frailty

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Unraveling how the interplay between Sargassum, plastic marine debris and Vibrio bacteria creates the perfect "pathogen" storm

Does obstructive sleep apnea increase the risk of post-acute sequelae of SARS-CoV-2?

Metabolically healthy and unhealthy 'forms' of obesity linked with increased risk of obesity-related cancers

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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