Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides that show angiogenic and mitogenic activities. The significance of VEGFs and receptors in tumorigenesis, angiogenesis, and neuroprotection makes them interesting targets for drug development.
The VEGF family members VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and PlGF attach in distinct patterns to three related receptor protein tyrosine kinases —VEGFR1/FLT1, VEGFR2/KDR, and VEGFR3/FLT4 — and two non-tyrosine kinase transmembrane proteins, neuropilin-1 (NRP1) and neuropilin-2 (NRP2).
The ligand-receptor attachment triggers the formation of homo- and heteromeric receptor complexes and enables downstream signaling.
Along with VEGF signaling, neuropilins also serve as co-receptors to various other signaling pathways, like those activated by Fibroblast Growth Factor (FGF), Insulin-like Growth Factor (IGF), Transforming Growth Factor beta (TGFβ), Hepatocyte Growth Factor (HGF), and Platelet-Derived Growth Factor (PDGF).
VEGF family ligands and receptors
More than 65 recombinant VEGF and receptor proteins that cover all VEGF family members and various isoforms of VEGF are provided by Sino Biological.
A great majority of these recombinant proteins are expressed in eukaryotic cells (human cells or insect cells), which affirms the right modification and greater activity of proteins.
High activity
Cell proliferation assay using human umbilical vein endothelial cells (HUVEC). Image Credit: Sino Biological Inc.
Inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC). Image Credit: Sino Biological Inc.
Recommended recombinant VEGF and receptor proteins
Source: Sino Biological Inc.
Cat#
Molecule
Species
Activity
Tag
10136-H02H
VEGFR1/FLT-1
Human
Active
hFc
10136-H08H
VEGFR1/FLT-1
Human
Active
His
10136-H08H1
VEGFR1/FLT-1
Human
Active
His
10806-H02H
VEGFR3/FLT4 (ECD)
Human
Active
hFc
50584-M02H
VEGFR3/FLT-4
Mouse
Active
hFc
10012-H02H
VEGFR2/KDR
Human
Active
hFc
10012-H02H1
VEGFR2/KDR (Domain 1&2&3)
Human
Active
hFc
10012-H02H1-B
VEGFR2/KDR (Domain 1&2&3)
Human
hFc
10012-H02H2
VEGFR2/KDR (Domain 2&3)
Human
Active
hFc
10012-H08H2
VEGFR2/KDR (Domain 2&3)
Human
His
10012-H20B1
VEGFR2/KDR
Human
Active
GST &
50998-M08H-B
VEGFR2/KDR
Mouse
Active
His
80113-R02H
VEGFR2/KDR
Rat
Active
hFc
80113-R08H
VEGFR2/KDR
Rat
His
90907-C08H
VEGFR2/KDR
Cynomolgus
His
10011-H08H
NRP1
Human
Active
His
10695-H02H
NRP2
Human
Active
hFc
11066-HNAB-B
VEGF165
Human,
Native
11066-HNAH
VEGF165
Human,
Active
Native
63004-ZNAB
VEGF165
Danio rerio
Active
Native
70004-DNAH
VEGF164
Canine
Active
Native
80006-RNAB
VEGF164
Rat
Active
Native
10544-H01H
VEGFB
Human
Active
hFc
80103-R01H
VEGFC (aa 108-223)
Mouse, Rat
Active
hFc
80103-R08H
VEGFC (aa 108-223)
Mouse, Rat
Active
His
50157-M01H
VEGFD
Mouse
Active
hFc
50157-M08H
VEGFD
Mouse
Active
His
80104-R01H
VEGFD
Rat
Active
hFc
10274-H05H
PIGF
Human
Active
mFc
VEGF/VEGFR antibodies
Sino Biological provides more than 100 antibodies against VEGF and receptor proteins with affirmed activities in numerous applications. The applications include immunohistochemistry, immunofluorescence, western blotting, flow cytometry, neutralization, and ELISA. The company also offers ELISA kits and ELISA pair sets.
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Video credit: Sino Biological